Houston Chronicle, Houston scientists see hope in cocaine vaccine:
“In concept, the idea seems simple. Cocaine (and many other drug) molecules are so small the immune system fails to recognize them and make the antibodies necessary to mount an attack. To help the immune system, Kosten attached inactivated cocaine to the outside of inactivated cholera proteins.
In response, the immune system not only makes antibodies to the combination, which is harmless, but also recognizes the potent naked drug when it’s ingested. The antibodies bind to the cocaine and prevent it from reaching the brain, where it normally would generate the highs that are so addictive.”
